Drug Discovery Services

ChemExpress is deeply committed to small-molecule drug discovery. Building on decades of discovery chemistry excellence, we integrate cutting-edge synthetic technologies, medicinal chemistry insight, and scalable development and manufacturing capabilities to empower pharmaceutical and biotech partners to advance small-molecule therapeutics with greater efficiency, quality, and regulatory confidence.

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One-Stop Small Molecule
CDMO Platform

From R&D to commercialization, we integrate CRO & CDMO capabilities across small molecules—delivering end-to-end services in RSM, intermediate, API, HPAPI and drug products.

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Green Chemistry &
Enabling Technology

We specialize in complex chemistry—chiral molecules, HPAPI, heterocycles, ADC linkers, and etc.—with enabling technologies including flow chemistry, High Throughput Experimentation, biocatalysis, and Solubility-Enhancing Technologies.

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Global Compliance &
Cost Efficiency

With Multiple GMP-compliant sites, we ensure regulatory excellence. Our tailored CDMO strategies help reduce costs, minimize tech transfer, and accelerate the path to market.

Our Services

We specialize in complex synthesis routes and accelerate drug discovery through flexible collaboration models and cost-effective R&D strategies.

Our Service Scope Includes

  • Milligram to Kilogram Synthesis of High-Quality Compounds
  • Target Validation & Identification
  • Hit Identification
  • Lead Compounds Optimization
  • Pre-clinical Drug Candidates Development
  • Generation of compounds for IND filing
  • Full-Time Equivalent (FTE) and Fee for Service (FFS) Services
  • IP Protection

Why Partner with ChemExpress

Broad Target & Pathway Coverage
Our discovery and development projects span over 20 signaling pathways and hundreds of druggable targets—including KRAS, PI3K, Bcl-2, HDAC, BET, CDK, JAK, ERK, EGFR, PD-1/PD-L1, GSK-3, and STING.
Proven Expertise in Process Chemistry
Our process chemists have extensive experience in route exploration, impurity control, and scale-up for complex compounds—including complex chiral APIs like Eribulin (19 chiral centers). We are experienced in synthesizing a wide range of molecule types, including small molecules, ADC payloads , PROTACs, peptides, and etc.
Advanced Technology Platforms
We leverage enabling technologies including high throughput experimentation (HTE), photochemistry, biocatalysis, flow chemistry, preparative chromatography, etc.
Extensive Project Experience
With over 70 medicinal chemistry projects completed and over 50 PCCs successfully delivered, an average productivity of around 3 to 7 compounds per FTE per month, earning the trust of pharmaceutical innovators worldwide.
Integrated Project Management
Experienced professional leadership, integrated project coordination across functions，with dual operation models of FTE and FFS for efficiency, responsiveness, and quality delivery.

Our Sites

R&D Sites

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Related Services

Process Development

We provide scalable and cost-effective processes, ensuring a smooth transition to GMP production and supporting technology transfer.

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Drug Substance Manufacturing

We provide integrated Drug Substance services—from early-stage process optimization to GMP production and regulatory support.

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Drug Product Manufacturing

We provide comprehensive manufacturing capabilities for multiple dosage forms, including oral solids (tablets, capsules, granules, powders) and semi-solids (creams, ointments, gels).

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Regulatory CMC Support

Well experienced with the regulatory management and requirements for pharmaceutical products in the USA, China, Japan and EU. We successfully assisted clients in a total of 140+ US-China dual IND filing cases.

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Analytical Development
& Quality Control

We provide comprehensive method development, validation, stability studies, ICH-compliant testing, and have fully equipped analytical instruments and GMP labs to ensure the quality of drug substances and drug products.

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