High-Throughput Experimentation (HTE)

ChemExpress has established High-Throughput Experimentation (HTE) platform to keep up with the increasing demand of pharmaceutical timelines in drug discovery and development. HTE is a powerful tool that allows the execution of large numbers of experiments in parallel while requiring limited material and less effort per-experiment. Taking these advantages, we are able to optimize individual steps in a total synthesis for solving complex chemical problems.

Reaction types

  • Metal-catalyzed cross coupling, Pd-carbonylation, C-H activiation, RCM, etc.
  • Heterogeneous hydrogenation, Asymmetric (transfer) hydrogenation
  • Bases, acids or Lewis acids catalyzed capability
  • Amide-formation
  • Chiral acids/bases resolution
  • Metal scavenger screening, salt-formation and crystalline polymorphs identification
  • Reaction development and optimization
  • Class variable screening
  • Catalyst Screening
  • Highly automated DoE
    (in progress)
  • Work-up development
  • Scavenger screening
  • High-throughput extraction
  • Crystallization development
  • Solid form and synthetic intermediate crystallization screening
  • Late-phase solubility