A comprehensive services of multi-chiral drug synthesis routes ranging from design and development, process optimization, pilot scale-up, quality research to industrial production.
Focus on the systematic research on solid forms of drug molecules, such as studies on crystal form and salt type, single crystal culture, process development, studies on particle size and fluidity, so as to provide systematic and professional support for R&D of downstream drug products.
Provide whole-process development services ranging from R&D to production of APIs as well as collation and application of pharmaceutical research data.
Carry out the research, development and production of vitamin D generic drugs, standard references for drug application, impurity study, drug product study, synthesis of active controls for new drug development, acquisition and modification of potentially active molecules of vitamin D analogs.
Carry out the development and production of ADC drug molecule and PROTAC molecule design, and provide products and technical services for related new drug development.
Provides independent design and development of building block and reference products. Predict the market demands and commercial values of related products through data analysis. Furnish the foundation of the company by taking the initiative to optimize the process, improve customer services and the industrialization application of products.
R&D and Services
Chemexpress is committed to creating a drug research and development service platform integrating CRO/CMC/CDMO of high-end APIs, providing products and technical services covering drug discovery, preclinical study, and clinical and full cycle of industrialization.
Chemexpress focuses on the development of APIs and intermediates of complex chiral drugs with high-tech barriers through the company's specialized and high-standard process research, quality management and project management systems. So far, we have developed over 100 APIs and intermediates, among which 84 products possess the foundation for industrialization. The products cover different fields such as anti-infection, diabetes, and cardio-cerebrovascular disease treatment.READ MORE +
Vitamin D derivatives generally have multiple chiral centers (>6) and have multi-step synthesis (10-20 steps). Their chemical synthesis also involves various special reactions such as chiral synthesis, ozonation and photochemical reaction. Vitamin D derivatives play a vital role in the treatment of rickets, renal osteodystrophy, osteoporosis, psoriasis, secondary hyperparathyroidism, and cancer. At present, the company has a reserve of more than ten Vitamin D derivatives projects, including calcipotriol, idecalcitol, maxacalcitol, paricalcitol, etc. with 2nd DMFs submitted for registration of many intermediates.READ MORE +
A high potency API generally means a highly active or high-potency drug with a dosage of less than 10 mg/day or with an occupational exposure limit (OEL) less than 10 μg/m3. High-potency APIs are usually drug molecules with complex structures with high value. They can act on the targets more selectively than other APIs and feature low dosage and high efficacy. At present, Chemexpress resides at advanced levels in the industry in terms of product quality, cost-effectiveness, and research timelines of many high-potency API projects.READ MORE +
ADC can reduce the adverse effects of the cytotoxic anti-tumor agents and improve the selectivity of tumor treatment. In addition, it serves as a better solution to deal with the drug resistance of targeted monoclonal antibodies. Its emergence fills the gap between antibody drugs and traditional chemotherapeutics, improving the drug specificity and the therapeutic window. As one of the pioneers carrying out the development and research of ADC in China, we have completed structure, polymorphs confirmation and impurity structure confirmation for some toxins, linkers and toxins-linkers. We have obtained the manufacturing process with stable quality through the implementation of a multi-chiral control strategy, thus achieving kilogram level supply.READ MORE +
Chemexpress independently develops, customizes, synthesize and optimize large number of compounds. Presently, we have synthesized over 10,000 kinds of building blocks and reference compounds with the scale varying from milligram to kilogram level. It includes product series of quinolines, azaindoles, tetralones, piperazines, pyrrolidines, cyclobutanes, spirocyclics, etc. These products are used in various stages of drug discovery, including pathway study, target discovery screening and lead optimization of compounds for preclinical studies.READ MORE +
Shanghai HaoyuanChemexpress Co., Ltd. was invited to attend The 2nd CMC-Expo China and API Summit to discuss the opportunities and challenges of the industry26 2020-10
President Dr. Zheng Baofu was invited to give a keynote speech on "Opportunities and Challenges of ADC drug CDMO services ". The Expo was held in Suzhou by PHARNEX and BioValley.
The 2nd CMC-Expo China，Shanghai HaoyuanChemexpress Co., Ltd. invites all colleagues to communicate!
Organic synthesis researcher, process researcher, crystal researcher, senior analyst, product manager, business manager……
Now we have become the internship base of many famous universities, and hold campus recruitment in spring and autumn every year. Chemexpress welcomes students to join the big family with warm and open attitude.
With a perfect promotion system and multiple training resources, we provide every employee with a platform for growth and development.
Project/performance bonus, flexible working system, holiday welfare, team building activities, variety activities, annual physical examination, children's daycare during winter and summer vacations……
We always adhere to the people-oriented concept, respect the talents and pay more attention to the talents. We provide every employee with a platform for learning and communication, greater development space and more care/ Join us, and show your talent to expand the infinite possibilities.
Promotion and Development